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Central to the physiologic maintenance of GFR is the differential basal tone of the afferent and efferent arterioles (see diagram).

In other words, the filtration rate is dependent on the difference between the higher blood pressure created by vasoconstriction of the input or afferent arteriole versus the lower blood pressure created lesser vasoconstriction of the output or efferent arteriole.

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Hence, an older woman with a serum creatinine of 1.4 mg/d L may actually have a moderately severe degree of renal insufficiency, whereas a young muscular male can have a normal level of renal function at this serum creatinine level.Dividing this mass by the plasma concentration gives the volume of plasma which the mass must have originally come from, and thus the volume of plasma fluid that has entered Bowman's capsule within the aforementioned period of time.

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